Nakada K, Kasai K, Watanabe Y, Katoh C, Kanegae K, Tsukamoto E, Itoh K, Tamaki N
Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Ann Nucl Med. 1996 Nov;10(4):441-4. doi: 10.1007/BF03164808.
A 62-year-old woman with metastatic papillary thyroid carcinoma in the sternum was successfully treated with percutaneous ethanol injection therapy (PET) when previous radioiodine therapy and external irradiation were ineffective. The patient tolerated the treatment well and the refractory pain in the anterior chest wall that was alleviated with morphine prior to PEIT completely disappeared. No severe complications were observed. PEIT was performed 4 times (2 times with ultrasound guidance and 2 times with CT guidance). The posttreatment CT scan and 201Tl scintigraphy demonstrated significant decrease in the tumor volume. The serum thyroglobulin level fell to less than one-twentieth of the pretreatment value. It is suggested that PEIT has a value in treating bone metastasis from thyroid carcinoma which do not respond to radioiodine.
一名62岁女性，胸骨出现转移性甲状腺乳头状癌，在先前的放射性碘治疗和外照射无效时，经皮乙醇注射治疗（PET）取得成功。患者对治疗耐受性良好，PEIT治疗前需用吗啡缓解的前胸壁顽固性疼痛完全消失。未观察到严重并发症。PEIT共进行了4次（2次在超声引导下，2次在CT引导下）。治疗后的CT扫描和201Tl闪烁显像显示肿瘤体积显著减小。血清甲状腺球蛋白水平降至治疗前值的二十分之一以下。提示PEIT在治疗对放射性碘无反应的甲状腺癌骨转移方面具有价值。
