Champion Patricia A DiGiuseppe, Cox Jeffery S
Department of Microbiology and Immunology, Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, 600 16th Street, Campus Box 2200, San Francisco, CA 94143-2200, USA.
Cell Microbiol. 2007 Jun;9(6):1376-84. doi: 10.1111/j.1462-5822.2007.00943.x. Epub 2007 Apr 25.
Mycobacteria have a unique cell-envelope structure which protects the bacteria from the extracellular environment by limiting access to noxious molecules from the outside. This extremely hydrophobic and thick barrier also poses a unique problem for the export of bacterial products. Here we review the multiple protein secretion pathways in Mycobacteria, including the general secretion pathway and the Twin-Arginine Transporter, with an emphasis on the ESX-1 alternate secretion system. This newly identified protein secretion system is required for growth during infection and has provided insight into how M. tuberculosis manipulates the host immune response during infection.
分枝杆菌具有独特的细胞包膜结构，该结构通过限制外界有害分子的进入来保护细菌免受细胞外环境的影响。这种极度疏水且厚实的屏障也给细菌产物的输出带来了独特的问题。在此，我们综述分枝杆菌中的多种蛋白质分泌途径，包括一般分泌途径和双精氨酸转运体，重点是ESX-1替代分泌系统。这个新发现的蛋白质分泌系统是感染期间生长所必需的，并为结核分枝杆菌在感染期间如何操纵宿主免疫反应提供了见解。
