Letra Ariadne, de Almeida Ana Lúcia Pompéia Fraga, Kaizer Rosane, Esper Luis Augusto, Sgarbosa Silvia, Granjeiro José Mauro
Department of Biological Sciences, Bauru Dental School, University of São Paulo, Bauru, SP, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 May;103(5):e38-41. doi: 10.1016/j.tripleo.2006.04.006. Epub 2006 Sep 7.
To evaluate the intraoral features of patients with Apert's syndrome in treatment at the Hospital of Rehabilitation and Craniofacial Anomalies of University of São Paulo (HRAC-USP), a national reference center for treatment of craniofacial anomalies in Brazil.
In this retrospective study, of 56,000 patients registered at HRAC-USP, 36 patients were diagnosed with Apert's syndrome and were either examined or had their medical files evaluated, aiming to characterize lip posture, mouth shape, maxillary hypoplasia, palatal morphology, dental anomalies, and malocclusion.
Most patients were characterized as mouth breathers for presenting with hypotonic lips and trapezoidal-shaped mouths. Other frequent findings were the presence of highly arched palates and hypoplastic maxilla, with gingival lateral swellings that increased in size with age. Crowding of teeth and malocclusion were commonly observed, and cases of hypodontia were frequent. Contrary to previous studies demonstrating a high incidence of cleft soft palate, in this study only 1 of 23 patients presented a true cleft.
The intraoral features of patients with Apert's syndrome in the population studied match most of the findings in other populations. However, the occurrence of cleft soft palate was unexpectedly low and morphologically normal teeth were found. In addition, hypodontia was frequently observed. Variations in frequency of observations of some characteristics might be related to differences in sample size or population.
评估在巴西颅面畸形治疗国家参考中心圣保罗大学康复与颅面畸形医院（HRAC-USP）接受治疗的Apert综合征患者的口腔内特征。
在这项回顾性研究中，对HRAC-USP登记的56000名患者进行研究，其中36例被诊断为Apert综合征，对他们进行了检查或评估其病历，旨在描述唇部姿势、口型、上颌发育不全、腭部形态、牙齿异常和错牙合畸形。
大多数患者因唇部张力减退和口型呈梯形而表现为口呼吸者。其他常见表现为高拱腭和上颌发育不全，牙龈外侧肿胀随年龄增长而增大。常见牙齿拥挤和错牙合畸形，且牙缺失病例频繁。与先前显示软腭裂高发率的研究相反，本研究中23例患者中只有1例出现真正的腭裂。
在所研究人群中，Apert综合征患者的口腔内特征与其他人群的大多数研究结果相符。然而，软腭裂的发生率出乎意料地低，且发现牙齿形态正常。此外，牙缺失情况频繁。某些特征观察频率的差异可能与样本量或人群差异有关。
