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阿佩尔综合征:牙科治疗的考量与目标

Apert Syndrome: Dental management considerations and objectives.

作者信息

Droubi Line, Laflouf Mohannad, Tolibah Yasser Alsayed, Comisi John C

机构信息

Department of Pediatric Dentistry, Faculty of Dental Medicine, Damascus University, Al-Mazzeh St., Damascus P.O. Box 3062, Syria.

Restorative Dentistry, Department of Oral Rehabilitation, Medical University of South Carolina James B. Edwards College of Dental Medicine, Charleston, South Carolina, USA.

出版信息

J Oral Biol Craniofac Res. 2022 May-Jun;12(3):370-375. doi: 10.1016/j.jobcr.2022.04.002. Epub 2022 Apr 28.

DOI:10.1016/j.jobcr.2022.04.002
PMID:35514675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9065907/
Abstract

BACKGROUND

Apert syndrome (AS) is a rare congenital disorder that correlates with many craniofacial features, like craniosynostosis, midfacial malformation, and symmetrical syndactyly of the hands and feet.

AIM

This paper describes the facial and oral manifestations in a 20-year-old female previously diagnosed with AS, discusses the complex dental treatment plan and treatments, including the use of a customized toothbrush handle to enhance the patient's brushing ability.

RESULTS

A satisfactory outcome was provided, and the patients quality of life improved significantly due to this comprehensive multi-disciplinary care process.

CONCLUSIONS

Comprehensive examination, extensive medical history reviewed, parental and patient consent are needed to establish a comprehensive treatment plan regarding the special needs of these patients.

摘要

背景

阿佩尔综合征(AS)是一种罕见的先天性疾病,与许多颅面特征相关,如颅缝早闭、面中部畸形以及手足对称性并指(趾)畸形。

目的

本文描述了一名先前被诊断为AS的20岁女性的面部和口腔表现,讨论了复杂的牙科治疗方案和治疗方法,包括使用定制牙刷柄以提高患者的刷牙能力。

结果

取得了满意的效果,并且由于这一全面的多学科护理过程,患者的生活质量得到了显著改善。

结论

需要进行全面检查、详细回顾病史、获得家长和患者同意,以制定针对这些患者特殊需求的综合治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e37/9065907/90b2771bcab0/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e37/9065907/90b2771bcab0/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e37/9065907/90b2771bcab0/ga1.jpg

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本文引用的文献

1
Dental approach for Apert syndrome in children: a systematic review.儿童Apert综合征的牙科治疗方法:一项系统评价
Med Oral Patol Oral Cir Bucal. 2017 Nov 1;22(6):e660-e668. doi: 10.4317/medoral.21628.
2
Definition of Special Health Care Needs.特殊医疗保健需求的定义。
Pediatr Dent. 2016 Oct;38(6):16.
3
Molecular analysis of exons 8, 9 and 10 of the fibroblast growth factor receptor 2 (FGFR2) gene in two families with index cases of Apert Syndrome.对两个患有阿佩尔综合征(Apert Syndrome)先证者的家系中,成纤维细胞生长因子受体2(FGFR2)基因的第8、9和10外显子进行分子分析。
影响牙齿萌出的代谢性骨病:一项叙述性综述
Children (Basel). 2024 Jun 20;11(6):748. doi: 10.3390/children11060748.
4
Unraveling the Complexity of Apert Syndrome: Genetics, Clinical Insights, and Future Frontiers.解析阿佩尔综合征的复杂性:遗传学、临床见解及未来前沿
Cureus. 2023 Oct 18;15(10):e47281. doi: 10.7759/cureus.47281. eCollection 2023 Oct.
Colomb Med (Cali). 2015 Sep 30;46(3):150-3.
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Mutations in the FGFR2 gene in Mexican patients with Apert syndrome.患有阿佩尔综合征的墨西哥患者FGFR2基因的突变
Genet Mol Res. 2015 Mar 27;14(1):2341-6. doi: 10.4238/2015.March.27.19.
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The molecular and cellular basis of Apert syndrome.阿佩尔综合征的分子和细胞基础。
Intractable Rare Dis Res. 2013 Nov;2(4):115-22. doi: 10.5582/irdr.2013.v2.4.115.
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Apert syndrome: a case report.阿佩尔综合征:一例病例报告。
Int J Clin Pediatr Dent. 2012 Sep;5(3):203-6. doi: 10.5005/jp-journals-10005-1166. Epub 2012 Dec 5.
7
Apert's Syndrome: Report of a New Case and its Management.阿佩尔综合征:一例新病例报告及其治疗
Int J Clin Pediatr Dent. 2008 Sep;1(1):48-53. doi: 10.5005/jp-journals-10005-1009. Epub 2008 Dec 26.
8
Cranio-maxillofacial, orthodontic and dental treatment in three patients with Apert syndrome.三名患有阿佩尔综合征患者的颅颌面、正畸和牙科治疗。
Eur Arch Paediatr Dent. 2014 Aug;15(4):281-9. doi: 10.1007/s40368-013-0105-9. Epub 2014 Mar 19.
9
Apert's syndrome: Report of a rare case.阿佩尔综合征:1例罕见病例报告。
J Oral Maxillofac Pathol. 2013 May;17(2):294-7. doi: 10.4103/0973-029X.119782.
10
Oral manifestations in Apert syndrome: case presentation and a brief review of the literature.
Rom J Morphol Embryol. 2010;51(3):581-4.