Staras Kevin
MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, London, UK.
Trends Neurosci. 2007 Jun;30(6):292-8. doi: 10.1016/j.tins.2007.04.005. Epub 2007 Apr 27.
Central presynaptic terminals harbour synaptic vesicles (SVs) and synapse-specific proteins necessary for neurotransmission. Classically, these elements were thought to reside more or less stably at individual mature synapses, giving rise to the idea that each terminal was essentially an independent functional unit. However, emerging evidence from fluorescence imaging studies in hippocampal cultured neurons is now challenging this view, suggesting that neighbouring synapses along axons share vesicles, and also other synaptic elements, at high levels. This raises the possibility that control of import and export might be an important regulatory target for the maintenance of release sites, modulation of synaptic efficacy and formation of new synaptic contacts. Here, temporal synaptic stability and the functional consequences for presynaptic operation will be considered.
中枢突触前终末含有神经传递所需的突触小泡（SVs）和突触特异性蛋白。传统上，这些成分被认为或多或少稳定地存在于单个成熟突触处，由此产生了每个终末本质上是一个独立功能单元的观点。然而，来自海马体培养神经元荧光成像研究的新证据正在挑战这一观点，表明沿轴突的相邻突触高水平共享小泡以及其他突触成分。这增加了一种可能性，即对输入和输出的控制可能是维持释放位点、调节突触效能和形成新突触连接的重要调控靶点。在此，将考虑突触的时间稳定性及其对突触前运作的功能影响。
