Refat Moamen S
Department of Chemistry, Faculty of Education, Suez-Canal University, Port Said, Egypt.
Spectrochim Acta A Mol Biomol Spectrosc. 2007 Dec 31;68(5):1393-405. doi: 10.1016/j.saa.2006.12.078. Epub 2007 Mar 3.
The investigation of the new structures of Ag(I), Cu(II) and Au(III) complexes, Ag(2)(Nor)(2)(2), [Cu(Nor)(2)(H(2)O)(2)]SO(4).5H(2)O and [Au(Nor)(2) (H(2)O)(2)]Cl(3) (where, Nor=norfloxacin) was done during the reaction of silver(I), copper(II) and gold(III) ions with norfloxacin drug ligand. Elemental analysis of CHN, infrared, electronic, (1)H NMR and mass spectra, as well as thermo gravimetric analysis (TG and DTG) and conductivity measurements have been used to characterize the isolated complexes. The powder XRD studies confirm the amorphous nature of the complexes. The norfloxacin ligand is coordinated to Ag(I) and Au(III) ions as a neutral monodentate chelating through the N atom of piperidyl ring, but the copper(II) complex is coordinated through the carbonyl oxygen atom (quinolone group) and the oxygen atom of the carboxylic group. The norfloxacin and their metal complexes have been biologically tested, which resulted in norfloxacin complexes showing moderate activity against the gram positive and gram negative bacteria as well as against fungi.
对银（I）、铜（II）和金（III）配合物Ag₂(Nor)₂₂、[Cu(Nor)₂(H₂O)₂]SO₄·5H₂O 和 [Au(Nor)₂(H₂O)₂]Cl₃（其中，Nor = 诺氟沙星）的新结构进行了研究，该研究是在银（I）、铜（II）和金（III）离子与诺氟沙星药物配体反应过程中进行的。采用 CHN 元素分析、红外光谱、电子光谱、¹H NMR 和质谱，以及热重分析（TG 和 DTG）和电导率测量对分离得到的配合物进行了表征。粉末 XRD 研究证实了配合物的无定形性质。诺氟沙星配体作为中性单齿螯合剂通过哌啶环的 N 原子与银（I）和金（III）离子配位，但铜（II）配合物是通过羰基氧原子（喹诺酮基团）和羧基氧原子配位的。对诺氟沙星及其金属配合物进行了生物学测试，结果表明诺氟沙星配合物对革兰氏阳性菌、革兰氏阴性菌以及真菌均表现出中等活性。
