Kudielka Brigitte M, Bellingrath Silja, Hellhammer Dirk H
Department of Theoretical and Clinical Psychobiology, University of Trier, Trier, Germany.
J Psychosom Res. 2007 May;62(5):595-6. doi: 10.1016/j.jpsychores.2007.03.016.
We analyzed free cortisol daytime levels in a "3-days-7-samples-a-day" protocol in relation to morningness in 112 middle-aged male and female adults derived from the first year of data of the Trier Teacher Stress Study using a one-item proxy for the assessment of chronotype. First, log-transformed cortisol levels were analyzed by a repeated-measures approach controlling for relevant covariates. Results yielded an almost significant main effect of morningness (P=.06). Subsequent within-day analyses, additionally controlling for awakening time, resulted in (marginally) significant main effects of morningness at Day 1 (P=.06) and Day 3 (P=.05) and a significant interaction of sample-by-morningness at Day 2 (P=.04). In sum, the present data seem to corroborate the idea of higher daytime cortisol levels in morning relative to evening types in a sample of healthy middle-aged male and female adults.
我们在“一天7个样本，共3天”的方案中，使用一个单项指标评估昼夜节律类型，分析了特里尔教师压力研究第一年数据中的112名中年男性和女性成年人的游离皮质醇日间水平与晨型的关系。首先，通过重复测量方法分析经对数转换的皮质醇水平，并控制相关协变量。结果显示晨型有近乎显著的主效应（P = 0.06）。随后的日内分析，额外控制了觉醒时间，结果显示第1天（P = 0.06）和第3天（P = 0.05）晨型有（边缘）显著的主效应，第2天样本与晨型有显著的交互作用（P = 0.04）。总之，目前的数据似乎证实了在健康中年男性和女性成年人样本中，相对于夜型，晨型的日间皮质醇水平更高这一观点。
