Kobayashi Makoto, Nakamura Kazufumi, Kusano Kengo Fukushima, Nakamura Yoichi, Ohta-Ogo Keiko, Nagase Satoshi, Sakuragi Satoru, Ohe Tohru
Int J Cardiol. 2008 Jun 6;126(3):427-9. doi: 10.1016/j.ijcard.2007.01.109. Epub 2007 Apr 30.
Immunological factors have been involved in the pathogenesis of dilated cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We examined whether MCP-1 was expressed in the myocardium of DCM patients and whether the expression level was correlated with the degree of impairment of cardiac function. The expression of MCP-1 in the myocardium was determined by immunohistochemistry in endomyocardial biopsy samples from 13 patients. The expression of MCP-1 was found in all myocardial samples from DCM patients but not in those from control subjects. Positive staining for MCP-1 was distinct in cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis revealed that the expression of MCP-1 was inversely correlated with left ventricular ejection fraction. In conclusion, the expression level of MCP-1 in the myocardium was correlated with the degree of impairment of cardiac function in patients with DCM.
免疫因素参与了扩张型心肌病（DCM）的发病机制。巨噬细胞的细胞毒性作用是导致心肌细胞损伤的主要因素之一。单核细胞趋化蛋白-1（MCP-1）是单核细胞/巨噬细胞聚集的主要信号。我们研究了DCM患者心肌中是否表达MCP-1，以及其表达水平是否与心功能损害程度相关。通过免疫组织化学法检测了13例患者心内膜活检样本心肌中MCP-1的表达。在DCM患者的所有心肌样本中均发现了MCP-1的表达，而对照组样本中未发现。MCP-1的阳性染色在心肌细胞、间质和浸润细胞中均明显。半定量分析显示，MCP-1的表达与左心室射血分数呈负相关。总之，DCM患者心肌中MCP-1的表达水平与心功能损害程度相关。
