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调节影响人类行为的主要基因变异:注意力缺陷多动障碍的时代错误

Tuning major gene variants conditioning human behavior: the anachronism of ADHD.

作者信息

Arcos-Burgos Mauricio, Acosta Maria Teresa

机构信息

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-1852, USA.

出版信息

Curr Opin Genet Dev. 2007 Jun;17(3):234-8. doi: 10.1016/j.gde.2007.04.011. Epub 2007 Apr 30.

DOI:10.1016/j.gde.2007.04.011
PMID:17467976
Abstract

New findings suggest that attention deficit and hyperactivity disorder (ADHD) is the most common behavioral variant associated with a mental condition. ADHD prevalence reaches figures of 18% in populations worldwide. Furthermore, genetic variants conferring susceptibility to develop ADHD are not rare but very frequent and eventually totally fixed in some populations. These patterns of evolution can be associated with the fact that this behavioral trait had provided selective advantage. However, this behavioral trait is now under scrutiny because of new emerging social necessities. Recent molecular and clinical evidence supports Thom Hartmann's Hunter-Farmer theory, reaffirming that ADHD might be an anachronic behavioral trait.

摘要

新的研究结果表明,注意力缺陷多动障碍(ADHD)是与精神状况相关的最常见行为变体。全球人群中ADHD的患病率达到18%。此外,导致易患ADHD的基因变体并非罕见,而是非常常见,最终在某些人群中完全固定下来。这些进化模式可能与这种行为特征曾提供选择优势这一事实有关。然而,由于新出现的社会需求,这种行为特征现在正受到审视。最近的分子和临床证据支持汤姆·哈特曼的猎人与农夫理论,再次证实ADHD可能是一种不合时宜的行为特征。

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