Densupsoontorn Narumon, Jirapinyo Pipop, Thamonsiri Nuchnoi, Wongarn Renu
Division of Nutrition, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkoknoi, Bangkok, 10700, Thailand.
Asia Pac J Clin Nutr. 2007;16(2):209-12.
Fructose malabsorption has not been well-defined in Thai populations but there has been increasing consumption of fructose-fortified drinks.
To assess the incidence of fructose malabsorption and intolerance in Thai normal subjects as well as the facilitating effect of glucose on fructose absorption.
Twenty-five gram of fructose was ingested by 77 subjects (37 men, 40 women; mean age 26 and 31 y, range 20-50 y and 21-50 y for men and women, respectively). Measurement of breath-H(2) levels after fructose ingestion in each subject up to 2 h was performed. Those who showed fructose malabsorption were later given 25 g of each glucose and fructose and second tests of breath-H(2) tests were done.
Fructose malabsorption was found in eleven females with a significant rise in average breath-H(2) level at 30, 60, 90, and 120 min (p< 0.001), whereas none of the males had an abnormal breath-H(2) test. Only 1 of the 11 females with increased breath H(2) had gastrointestinal symptoms. In all the fructose malabsorbers, excess breath-H(2) reverted to normal when the fructose solution was mixed and administered with 25 g glucose (p< 0.001).
The incidence rate of fructose malabsorption was 11 of 77 subjects but these were female. One of the 11 had gastrointestinal symptoms. It was found that an equal amount of glucose would abolish fructose malabsorption.
果糖吸收不良在泰国人群中尚未得到明确界定，但含果糖强化饮料的消费量却在不断增加。
评估泰国正常受试者中果糖吸收不良和不耐受的发生率，以及葡萄糖对果糖吸收的促进作用。
77名受试者（37名男性，40名女性；男性平均年龄26岁，年龄范围20 - 50岁，女性平均年龄31岁，年龄范围21 - 50岁）摄入25克果糖。在每位受试者摄入果糖后2小时内测量呼气中氢气（H₂）水平。对显示果糖吸收不良的受试者随后分别给予25克葡萄糖和果糖，并再次进行呼气H₂测试。
在11名女性中发现果糖吸收不良，在30、60、90和120分钟时平均呼气H₂水平显著升高（p < 0.001），而男性中无人呼气H₂测试异常。11名呼气H₂升高的女性中只有1人有胃肠道症状。在所有果糖吸收不良者中，当果糖溶液与25克葡萄糖混合服用时，过量的呼气H₂恢复正常（p < 0.001）。
77名受试者中有11人发生果糖吸收不良，但均为女性。11人中1人有胃肠道症状。发现等量的葡萄糖可消除果糖吸收不良。
