Galetta S L, Plock G L, Kushner M J, Wyszynski R E, Brucker A J
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia.
Ann Ophthalmol. 1991 Jun;23(6):207-12.
Four patients with isolated acute ocular ischemic syndromes also had circulating antiphospholipid antibodies. Two patients had vaso-occlusive retinopathy and two, anterior ischemic optic neuropathy (which was successive in one). Extensive clinical laboratory evaluation identified vascular risk factors in two patients. One patient had essential thrombocytosis, confirmed by bone marrow biopsy; the other had stable hypertension and a history of coronary artery disease. These cases suggest that small vessel thrombosis in situ may be a mechanism for antiphospholipid-associated ocular and cerebral ischemia.
4例孤立性急性眼部缺血综合征患者也存在循环抗磷脂抗体。2例患有血管闭塞性视网膜病变，2例患有前部缺血性视神经病变（其中1例为相继发生）。广泛的临床实验室评估在2例患者中发现了血管危险因素。1例经骨髓活检确诊为原发性血小板增多症；另1例患有稳定型高血压和冠状动脉疾病史。这些病例表明，原位小血管血栓形成可能是抗磷脂相关眼部和脑部缺血的一种机制。
