Ticho U, Ophir A
Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.
Ann Ophthalmol. 1991 Jun;23(6):225-9.
Repeated doses of 5mg of 5-fluorouracil (5-FU) were injected subconjunctivally in 25 poor-prognosis glaucomatous eyes after filtering surgery to prevent filtering bleb scarring. The frequency (1-2 times a day) and duration (minimum, 7 days) of injections were determined by the degree of the anterior chamber reaction and/or conjunctival hyperemia at the filtering bleb site. Punctate corneal erosions or filaments were not considered a contraindication to continuation of 5-FU treatment. After 12 months, intraocular pressure (IOP) of 16 mmHg or less without medical treatment was found in 19 (76%) eyes. In 16 of these (64%), the IOP was 12 mmHg or less. In two (8%) other eyes, it was 20 mmHg or less with medication. We believe that the comparatively low IOP levels achieved without medical treatment in 76% of the eyes in our study can be attributed in part to our therapeutic approach with 5-FU.
对25只滤过性手术后预后较差的青光眼患眼进行结膜下重复注射5毫克5-氟尿嘧啶（5-FU），以防止滤过泡瘢痕形成。注射频率（每天1-2次）和持续时间（至少7天）根据滤过泡部位的前房反应程度和/或结膜充血情况确定。点状角膜糜烂或丝状角膜炎不被视为继续5-FU治疗的禁忌证。12个月后，19只（76%）患眼在未接受药物治疗的情况下眼压（IOP）降至16 mmHg或更低。其中16只（64%）患眼的眼压为12 mmHg或更低。另外两只（8%）患眼在使用药物治疗后眼压为20 mmHg或更低。我们认为，在我们的研究中，76%的患眼在未接受药物治疗的情况下实现了相对较低的眼压水平，这部分可归因于我们使用5-FU的治疗方法。
