Ophir A, Ticho U
Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.
Eye (Lond). 1990;4 ( Pt 6):819-22. doi: 10.1038/eye.1990.129.
In five glaucoma patients, a previous filtering surgery that was followed by sub-conjunctival injections of 5-Fluorouracil (5-FU) failed, due to filtering bleb scarring. A repetition of the filtering surgery with subsequent sub-conjunctival injections of 5 mg of 5-FU, administered once daily for 8-14 days, was undertaken. At the end of 6-19 months of follow-up, IOP levels in all five eyes were 20 mmHg or less with medication. A repeated course of filtering surgery plus 5-FU treatment seems to be a favourable surgical option in refractory glaucoma.
在5例青光眼患者中，先前的滤过手术联合结膜下注射5-氟尿嘧啶（5-FU）失败，原因是滤过泡瘢痕形成。于是进行了重复滤过手术，并在术后结膜下注射5 mg 5-FU，每天1次，持续8 - 14天。在6 - 19个月的随访结束时，所有5只眼在使用药物的情况下眼压水平均在20 mmHg或更低。重复进行滤过手术加5-FU治疗似乎是难治性青光眼的一种有利手术选择。
