Zou Chao Chun, Liang Li, Hong Fang
Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou 310 003, China.
Indian Pediatr. 2007 Apr;44(4):275-9.
The aim is to study the relationship between insulin resistance and serum adiponectin and resistin in obese children.
A total 113 obese and 37 nonobese children were enrolled and serum adiponectin and resistin were measured.
Compared with controls, higher insulin resistance by homeostasis model (HOMA-IR) and lower whole body insulin resistance index (WBISI)were found in obese children (all P <0.05). The adiponectin levels in obese children and controls were 3.63 and 5.79 microg/L with a significant difference (P<0.001) while the difference of resistin levels was not significant (P = 0.948). Significant correlations between insulin resistance parameter and age,sexual development, BMI, serum triglyceride, ApoB, LDL-cholesterol, HDL-cholesterol, alanine aminotransferase, uric acid, or adiponectin levels (all P <0.05) were noted. Stepwise multiple regression analysis showed that BMI and adiponectin levels were independent determinants of WBISI.
These results suggest that adiponectin may play a protective role in obese children through decreasing insulin resistance.
研究肥胖儿童胰岛素抵抗与血清脂联素及抵抗素之间的关系。
纳入113名肥胖儿童和37名非肥胖儿童，检测血清脂联素和抵抗素水平。
与对照组相比，肥胖儿童采用稳态模型评估的胰岛素抵抗（HOMA-IR）更高，全身胰岛素抵抗指数（WBISI）更低（均P<0.05）。肥胖儿童和对照组的脂联素水平分别为3.63和5.79μg/L，差异有统计学意义（P<0.001），而抵抗素水平差异无统计学意义（P = 0.948）。胰岛素抵抗参数与年龄、性发育、BMI、血清甘油三酯、载脂蛋白B、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、丙氨酸氨基转移酶、尿酸或脂联素水平之间均存在显著相关性（均P<0.05）。逐步多元回归分析显示，BMI和脂联素水平是WBISI的独立决定因素。
这些结果表明，脂联素可能通过降低胰岛素抵抗对肥胖儿童起到保护作用。
