胰岛素抵抗与脂联素及抵抗素血清水平与儿童肥胖的关系。

Relationship between insulin resistance and serum levels of adiponectin and resistin with childhood obesity.

作者信息

Zou Chao Chun, Liang Li, Hong Fang

机构信息

Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou 310 003, China.

出版信息

Indian Pediatr. 2007 Apr;44(4):275-9.

PMID:17468522

Abstract

OBJECTIVE

The aim is to study the relationship between insulin resistance and serum adiponectin and resistin in obese children.

METHODS

A total 113 obese and 37 nonobese children were enrolled and serum adiponectin and resistin were measured.

RESULTS

Compared with controls, higher insulin resistance by homeostasis model (HOMA-IR) and lower whole body insulin resistance index (WBISI)were found in obese children (all P <0.05). The adiponectin levels in obese children and controls were 3.63 and 5.79 microg/L with a significant difference (P<0.001) while the difference of resistin levels was not significant (P = 0.948). Significant correlations between insulin resistance parameter and age,sexual development, BMI, serum triglyceride, ApoB, LDL-cholesterol, HDL-cholesterol, alanine aminotransferase, uric acid, or adiponectin levels (all P <0.05) were noted. Stepwise multiple regression analysis showed that BMI and adiponectin levels were independent determinants of WBISI.

CONCLUSIONS

These results suggest that adiponectin may play a protective role in obese children through decreasing insulin resistance.

摘要

目的

研究肥胖儿童胰岛素抵抗与血清脂联素及抵抗素之间的关系。

方法

纳入113名肥胖儿童和37名非肥胖儿童，检测血清脂联素和抵抗素水平。

结果

与对照组相比，肥胖儿童采用稳态模型评估的胰岛素抵抗（HOMA-IR）更高，全身胰岛素抵抗指数（WBISI）更低（均P<0.05）。肥胖儿童和对照组的脂联素水平分别为3.63和5.79μg/L，差异有统计学意义（P<0.001），而抵抗素水平差异无统计学意义（P = 0.948）。胰岛素抵抗参数与年龄、性发育、BMI、血清甘油三酯、载脂蛋白B、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、丙氨酸氨基转移酶、尿酸或脂联素水平之间均存在显著相关性（均P<0.05）。逐步多元回归分析显示，BMI和脂联素水平是WBISI的独立决定因素。