Cole Jason C, Lin Peggy, Rupnow Marcia F T
QualityMetric, 640 George Washington Highway, Suite 201, Lincoln, RI 02865, USA.
Qual Life Res. 2007 Sep;16(7):1231-7. doi: 10.1007/s11136-007-9217-1. Epub 2007 Apr 28.
Health-related quality of life (HRQoL) is an important outcome measure of migraine treatments. Although a number of migraine-specific HRQoL questionnaires exist, their measurement characteristics have only been examined for patients undergoing acute treatment of migraine. The goal of the current study was to evaluate measurement properties of the widely used Migraine-Specific Quality of Life Questionnaire version 2.1 (MSQ v. 2.1) within a group of patients undergoing prophylactic migraine treatment.
Various measurement properties of the MSQ were examined in a sample of 916 migraineurs undergoing prophylactic treatment who had scores at baseline and follow-up, as well as baseline SF-36. First, we used confirmatory factor analysis (CFA) and differential item functioning (DIF) to assure the accuracy and stability across groups of the MSQ scoring for all three subscales (Role Restrictive, Role Preventive, and Emotional Functioning). Next, item- and scale-level properties were examined, such as item-total correlations, internal consistency, and convergent and discriminant validity.
Initial findings revealed that item 12 (measuring frustration on the Emotional Functioning subscale) performed poorly. Subsequent to its removal, the 13-item MSQ displayed excellent measurement properties, including stable latent structure at baseline and endpoint, no gender or age biases on items, appropriate item-level and scale-level reliabilities, and markedly higher convergent validity compared to discriminant validity.
The 13-item MSQ appears to be an appropriate measure of migraine-specific HRQoL for patients undergoing migraine prophylaxis. Moreover, given the stability of the latent structure over time, the interpretation of scores is likely to remain quite consistent throughout a clinical trial.
健康相关生活质量（HRQoL）是偏头痛治疗的一项重要结果指标。尽管存在一些针对偏头痛的HRQoL问卷，但其测量特性仅在接受偏头痛急性治疗的患者中进行过检验。本研究的目的是评估在一组接受偏头痛预防性治疗的患者中广泛使用的偏头痛特异性生活质量问卷第2.1版（MSQ v. 2.1）的测量特性。
在916名接受预防性治疗的偏头痛患者样本中检验了MSQ的各种测量特性，这些患者在基线和随访时有评分，同时还有基线SF-36评分。首先，我们使用验证性因子分析（CFA）和差异项目功能（DIF）来确保MSQ所有三个子量表（角色限制、角色预防和情绪功能）评分在各组间的准确性和稳定性。接下来，检验了项目和量表层面的特性，如项目与总分的相关性、内部一致性以及收敛效度和区分效度。
初步结果显示项目12（测量情绪功能子量表上的挫败感）表现不佳。去除该项目后，13项MSQ显示出优异的测量特性，包括在基线和终点时稳定的潜在结构、项目上无性别或年龄偏差、适当的项目层面和量表层面信度，以及与区分效度相比明显更高的收敛效度。
13项MSQ似乎是偏头痛预防性治疗患者偏头痛特异性HRQoL的合适测量工具。此外，鉴于潜在结构随时间的稳定性，在整个临床试验中分数的解释可能会保持相当一致。
