Berstad Paula, Ma Huiyan, Bernstein Leslie, Ursin Giske
Institute of Basic Medical Sciences, Department of Nutrition, University of Oslo, Oslo, Norway.
Breast Cancer Res Treat. 2008 Mar;108(1):113-20. doi: 10.1007/s10549-007-9578-8. Epub 2007 Apr 28.
Alcohol intake has been consistently associated with breast cancer risk, but the importance of timing of intake and the impact of beverage type are unclear.
We evaluated whether early, lifetime or recent alcohol intake was associated with breast cancer risk, and whether risk varied by type of alcoholic drinks in 1,728 newly diagnosed population-based breast cancer patients and 435 control subjects aged 20-49 years. We used multivariable logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (CI) as measures of the relative risk of breast cancer associated with intake of alcoholic drinks.
Intake of alcoholic drinks during the recent five year period before the breast cancer diagnosis was associated with increased breast cancer risk (P (trend) = 0.04). Intake of two or more alcoholic drinks per day during this five year period was associated with an 82% increase in breast cancer risk relative to never drinkers (OR = 1.82, 95% CI = 1.01-3.28). No risk increase was observed for alcohol intake at ages 15-20 years or for lifetime alcohol intake. Risk did not vary by type of alcohol consumed.
Our results suggest that recent alcohol consumption may be associated with increased breast cancer risk in young women.
饮酒一直与乳腺癌风险相关，但饮酒时间的重要性以及饮料类型的影响尚不清楚。
我们评估了早期、终生或近期饮酒是否与乳腺癌风险相关，以及在1728名新诊断的基于人群的乳腺癌患者和435名年龄在20 - 49岁的对照受试者中，乳腺癌风险是否因酒精饮料类型而异。我们使用多变量逻辑回归模型来估计比值比（OR）和95%置信区间（CI），作为与酒精饮料摄入相关的乳腺癌相对风险的度量。
在乳腺癌诊断前的最近五年内饮酒与乳腺癌风险增加相关（P（趋势）= 0.04）。在这五年期间每天饮用两种或更多酒精饮料与从不饮酒者相比，乳腺癌风险增加了82%（OR = 1.82，95% CI = 1.01 - 3.28）。在15 - 20岁时饮酒或终生饮酒未观察到风险增加。风险不因所消费的酒精类型而有所不同。
我们的结果表明，近期饮酒可能与年轻女性乳腺癌风险增加有关。
