Carrada-Bravo Teodoro
Infectólogo, Jefe Regional de Educación Médica e Investigación, Hospital General de Zona y Medicina Familiar 2, Instituto Mexicano del Seguro Social, Irapuato, Guanajuato, Mexico.
Arch Cardiol Mex. 2006 Oct-Dec;76 Suppl 4:S189-96.
Cardiovascular tertiary syphilis may lead to aortitis, aortic aneurism, coronary stenosis, aortic insufficiency and, rarely, to myocarditis. The physician must be familiar with the clinical presentations of this process, including the asymptomatic variety and must be able to have an organized plan for the diagnosis and evaluation to establish or exclude the presence of cardiovascular pathology and the differential diagnosis with other entities. Once the etiologic and topographic diagnosis is established, the patient should be treated with penicillin, doxicycline and other antibiotics, and the consequences of the disorder, both actual and potential, should be considered before deciding weather to recommend surgical intervention. Although late syphilis can be prevented by appropriate therapy of early syphilis, this is a cardiovascular disease that most likely will continue to be diagnosed lately. Understanding of the pathology and pathophysiology of the disease, is most important for its prompt recognition and subsequent management. This paper reviews the natural history, diagnosis and therapy of cardiovascular syphilis.
心血管三期梅毒可导致主动脉炎、主动脉瘤、冠状动脉狭窄、主动脉瓣关闭不全,罕见情况下还可导致心肌炎。医生必须熟悉这一病程的临床表现,包括无症状型,并且必须能够制定有条理的诊断和评估计划,以确定或排除心血管病变的存在以及与其他病症的鉴别诊断。一旦确立病因和部位诊断,就应使用青霉素、多西环素和其他抗生素对患者进行治疗,在决定是否建议手术干预之前,应考虑该病症的实际和潜在后果。虽然早期梅毒的适当治疗可预防晚期梅毒,但这是一种很可能仍会被延迟诊断的心血管疾病。了解该疾病的病理学和病理生理学,对其及时识别和后续处理最为重要。本文综述了心血管梅毒的自然史、诊断和治疗。