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[非静脉曲张性上消化道出血的内镜检查]

[Endoscopy in non-variceal upper gastrointestinal bleeding].

作者信息

Ballesteros Amozurrutia Mario Arturo

机构信息

Gastroenterólogo, Hospital Angeles del Pedregal, Mexico, D.F.

出版信息

Rev Gastroenterol Mex. 2005 Jul;70 Suppl 1:48-62.

Abstract

Non variceal upper gastrointestinal bleeding (NVUGIB) still is a common cause of hospital admissions, morbidity and a significant mortality. A decrease trend has recently been documented thank to the general use of therapeutic endoscopy in spite of a greater use of non steroidal antinflamatory agents (NSAID) and a growing senile population. Most of NVUGIB are caused by peptic ulcer (PU) and usually stop spontaneously, but 15% of cases need endoscopic or surgical intervention. Clinically these patients can be identified by the presence of shock, orthostatic hypotension or associated organ failures (Rockall scale) and by endoscopic findings of active bleeding or non bleeding visible vessel (Forrest scale) both useful and complimentary. There are diverse endoscopic techniques to halt NVUGIB, with transendoscopic saline injection with or w/o epinephrine + coaptive bipolar electrocoagulation or heater probe being the gold standard with 85 to 90% initial success, and furthermore stopping recurrences in similar figures. Under these circumstances new methods as argon plasma electrocoagulation or mechanic methods such as endoclips or banding have difficulty to demonstrate their usefulness when compared to established procedures, but still may have some indications such as diffuse gastric or vascular lesions for argon plasma electrocoagulation, and bands or endoclips for deep ulcers given their lower risk of perforation. Antisecretory agents are useful complementary treatment decreasing recurrence by 8% when used at high doses. Hp eradication decreases PU and NVUGIB recurrence, except in patients who ingest NSAID on a regular basis who require nocturnal antisecretory treatment.

摘要

非静脉曲张性上消化道出血(NVUGIB)仍然是住院、发病和高死亡率的常见原因。尽管非甾体抗炎药(NSAID)的使用增加且老年人口不断增长,但由于治疗性内镜的广泛应用,最近已有下降趋势的记录。大多数NVUGIB由消化性溃疡(PU)引起,通常可自行停止,但15%的病例需要内镜或手术干预。临床上,这些患者可通过休克、体位性低血压或相关器官衰竭的存在(Rockall评分)以及内镜下活动性出血或非出血可见血管的发现(Forrest评分)来识别,这两者都很有用且相辅相成。有多种内镜技术可用于止血NVUGIB,经内镜注射生理盐水加或不加肾上腺素联合双极电凝或热探头是金标准,初始成功率为85%至90%,而且在类似比例的病例中可防止复发。在这种情况下,与既定程序相比,氩等离子体电凝等新方法或诸如内镜夹闭或套扎等机械方法难以证明其有效性,但对于弥漫性胃或血管病变等情况,氩等离子体电凝仍可能有一些适应证,而对于深部溃疡,内镜夹或套扎因其穿孔风险较低也可能有一些适应证。抗分泌药物是有用的辅助治疗,高剂量使用时可使复发率降低8%。根除幽门螺杆菌可降低PU和NVUGIB的复发率,但经常服用NSAID的患者除外,这类患者需要夜间抗分泌治疗。

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