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[肝移植术后胆道并发症的内镜治疗]

[Endoscopic management of biliary complications after liver transplantation].

作者信息

Carlson Christopher J, Kowdley Kris V

机构信息

University of Washington, Seattle 98195, USA.

出版信息

Rev Gastroenterol Mex. 2005 Jul;70 Suppl 1:107-20.

Abstract

Biliary complications are common in liver transplant recipients and may develop in up to one-third of all patients. Bile leaks generally occur within the first 3 months and are frequently related to T-tube removal. The recent trend to avoid of T-tubes has probably resulted in a reduced incidence of such bile leaks. The other major biliary complications in liver transplant recipients include biliary strictures, choledocholithiasis, biliary casts and sphincter of Oddi dysfunction. Biliary strictures can be classified into anastomotic and non-anastomotic strictures. Anastomotic strictures are generally related to technical complications of choledochocholedochostomy, while non-anastomotic strictures are frequently related to hepatic artery thrombosis. The overwhelming majority of biliary complications choledochocholedochostomy can be managed by endoscopic means, ranging from use of plastic stents, balloon dilation or endoscopic sphincteromoty. Surgical revision may be required in rare instances such as recurrent biliary casts or large caliber leaks associated with anastomotic strictures. The purpose of this review is to review the incidence, risk factors for and pathogenesis of biliary complications after liver transplantation. The results of endoscopic management of these strictures is also described in detail and should be of interest to therapeutic endoscopists, liver transplant physicians, transplant surgeons and therapeutic endoscopists.

摘要

胆系并发症在肝移植受者中很常见,所有患者中高达三分之一可能会发生。胆漏通常发生在术后前3个月内,且常与T管拔除有关。近来避免使用T管的趋势可能已使此类胆漏的发生率降低。肝移植受者的其他主要胆系并发症包括胆管狭窄、胆总管结石、胆泥及Oddi括约肌功能障碍。胆管狭窄可分为吻合口狭窄和非吻合口狭窄。吻合口狭窄一般与胆总管-胆总管吻合术的技术并发症有关,而非吻合口狭窄常与肝动脉血栓形成有关。绝大多数胆总管-胆总管吻合术相关的胆系并发症可通过内镜手段处理,包括使用塑料支架、球囊扩张或内镜下括约肌切开术。在罕见情况下,如复发性胆泥或与吻合口狭窄相关的大口径胆漏,可能需要进行手术修正。本综述的目的是回顾肝移植术后胆系并发症的发生率、危险因素及发病机制。还详细描述了这些狭窄的内镜治疗结果,治疗内镜医师、肝移植内科医生、移植外科医生及治疗内镜医师可能会对此感兴趣。

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