Ivanova-Todorova E I, Aĭvazova N, Mekhandzhiev Ts R, Nalbanski A, Chernev T, Kiurkchiev D S
Akush Ginekol (Sofiia). 2007;46(2):3-8.
From an immunological point of view during pregnancy the interactions between the steroid sex hormones and immunocompetent cells as a part of the dynamic local and peripheral immune response is of a particular interest. The aim of our study is to investigate the expression of the early activation marker CD69 in T-lymphocytes subpopulation: CD4+ and CD8+ in peripheral blood from pregnant and non-pregnant women. Our data clearly demonstrate an increase of the percentage of activated CD4+ lymphocytes in pregnant women in comparison to non-pregnant and this difference is statistically significant. A similar but not statistically significant dependency is observed in CD8+ and CD69+ lymphocytes. From the obtained results we conclude that during pregnancy the activation of CD4+ lymphocytes is increased, which probably leads to an increased production of cytokines that shifts the immune response to Th2 type which is protective for pregnancy. This could be partly due to the increased levels of progesterone.
从免疫学角度来看，在孕期，作为动态局部和外周免疫反应一部分的甾体性激素与免疫活性细胞之间的相互作用尤为引人关注。我们研究的目的是调查早期激活标志物CD69在孕妇和非孕妇外周血T淋巴细胞亚群（CD4+和CD8+）中的表达情况。我们的数据清楚地表明，与非孕妇相比，孕妇中活化CD4+淋巴细胞的百分比增加，且这种差异具有统计学意义。在CD8+和CD69+淋巴细胞中观察到类似但无统计学意义的相关性。根据所得结果我们得出结论，孕期CD4+淋巴细胞的活化增加，这可能导致细胞因子产生增加，从而使免疫反应向对妊娠有保护作用的Th2型转变。这可能部分归因于孕酮水平的升高。
