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[咖啡因和氟化钠对大鼠血清氟浓度及其牙齿和骨骼中氟含量的影响]

[The effect of caffeine and sodium fluoride on fluoride concentration in serum and its content in teeth and bones of rats].

作者信息

Grucka-Mamczar Ewa, Chlubek Dariusz, Birkner Ewa, Zalejska-Fiolka Jolanta, Błaszczyk Iwona, Kasperczyk Sławomir, Stawiarska-Pieta Barbara

机构信息

Zakład Biochemii Ogólnej, Katedra Biochemii Slqskiej Akademii Medycznej w Katowicach ul. Jordana 19, 41-808 Zabrze.

出版信息

Ann Acad Med Stetin. 2006;52 Suppl 1:37-40.

PMID:17469500
Abstract

PURPOSE

The aim of this work was to determine the effect of sodium fluoride at a dose of 4.9 mg/kg b.w./24 h and caffeine at a dose of 3 mg/kg b.w./24 h on the concentration of fluoride in serum and its content in teeth and bones of rats.

MATERIAL AND METHODS

The study was done in 18 male Sprague-Dawley rats.

CONCLUSIONS

A negative effect of caffeine administered concurrently with sodium fluoride on teeth and bones of rats was demonstrated as reflected by a tendency to increased content of fluoride in bones and decreased content in teeth.

摘要

目的

本研究旨在确定剂量为4.9毫克/千克体重/24小时的氟化钠和剂量为3毫克/千克体重/24小时的咖啡因对大鼠血清氟浓度及其牙齿和骨骼中氟含量的影响。

材料与方法

该研究在18只雄性斯普拉格-道利大鼠身上进行。

结论

与氟化钠同时给予咖啡因对大鼠牙齿和骨骼有负面影响，表现为骨骼中氟含量有增加趋势，而牙齿中氟含量降低。

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