Synthesis and characterization of a dehydrogenation product arising from the oxidation of aminoethylcysteine ketimine decarboxylated dimer.

作者信息

Macone Alberto, Caiazzo Aldo, Antonucci Antonio, Fochi Igor, Nardini Mirella, Duprè Silvestro, Matarese Rosa Marina

机构信息

Department of Biochemical Sciences A. Rossi-Fanelli and National Research Council Institute of Molecular Biology and Pathology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy.

出版信息

J Nat Prod. 2007 Jun;70(6):1046-8. doi: 10.1021/np060641t. Epub 2007 May 1.

DOI:10.1021/np060641t

PMID:17469872

Abstract

While investigating the antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer (1) (a natural substance occurring in biological fluids such as human urine and plasma and in bovine cerebellum), a previously unreported oxidation product was obtained. This compound was identified and characterized through comparison with an authentic sample prepared via Pd-catalyzed dehydrogenation of 1. This molecule is an example of an alternative oxidation pathway involving 1.

摘要