Macone Alberto, Fontana Mario, Barba Marco, Botta Bruno, Nardini Mirella, Ghirga Francesca, Calcaterra Andrea, Pecci Laura, Matarese Rosa Marina
Department of Biochemical Sciences, Sapienza, University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy; E-Mails:
Int J Mol Sci. 2011;12(5):3072-84. doi: 10.3390/ijms12053072. Epub 2011 May 12.
Aminoethylcysteine ketimine decarboxylated dimer is a natural sulfur-containing compound detected in human plasma and urine, in mammalian brain and in many common edible vegetables. Over the past decade many studies have been undertaken to identify its metabolic role. Attention has been focused on its antioxidant properties and on its reactivity against oxygen and nitrogen reactive species. These properties have been studied in different model systems starting from plasma lipoproteins to specific cellular lines. All these studies report that aminoethylcysteine ketimine decarboxylated dimer is able to interact both with reactive oxygen and nitrogen species (hydrogen peroxide, superoxide anion, hydroxyl radical, peroxynitrite and its derivatives). Its antioxidant activity is similar to that of Vitamin E while higher than other hydrophilic antioxidants, such as trolox and N-acetylcysteine.
氨基乙基半胱氨酸酮亚胺脱羧二聚体是一种在人体血浆和尿液、哺乳动物大脑以及许多常见食用蔬菜中检测到的天然含硫化合物。在过去十年中，人们进行了许多研究来确定其代谢作用。注意力集中在其抗氧化特性以及对氧和氮活性物种的反应性上。从血浆脂蛋白到特定细胞系，这些特性已在不同的模型系统中进行了研究。所有这些研究都报告称，氨基乙基半胱氨酸酮亚胺脱羧二聚体能够与活性氧和氮物种（过氧化氢、超氧阴离子、羟基自由基、过氧亚硝酸盐及其衍生物）相互作用。其抗氧化活性与维生素E相似，但高于其他亲水性抗氧化剂，如曲洛克斯和N-乙酰半胱氨酸。
