Shtasel D L, Gur R E, Mozley P D, Richards J, Taleff M M, Heimberg C, Gallacher F, Gur R C
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104-4283.
Arch Gen Psychiatry. 1991 Nov;48(11):1022-5. doi: 10.1001/archpsyc.1991.01810350062010.
We examined the process of accruing healthy control subjects for biomedical research on brain function. Of 1670 responders to newspaper advertising, 23.1% were uninterested when learning more about the studies, and 50.9% of those remaining were found by structured telephone screening to meet exclusionary criteria for having a history of psychiatric, neurologic, or medical disease that might affect brain function. Of 312 volunteers passing the telephone screening who came to an in-person evaluation by a physician and agreed to participate, 49.7% were found to meet exclusionary criteria, and only 157 were admitted to the study. This underscores the importance of attending to the issue of screening and assessment of "normal volunteers." Alternative strategies should be considered for enriching the pool.
我们研究了为脑功能生物医学研究招募健康对照受试者的过程。在1670名回应报纸广告的人中，23.1%在了解更多研究信息后不感兴趣，而其余人中，经结构化电话筛选发现有50.9%因有可能影响脑功能的精神、神经或医学疾病史而符合排除标准。在通过电话筛选并前来接受医生当面评估且同意参与的312名志愿者中，49.7%被发现符合排除标准，最终只有157人被纳入研究。这凸显了关注“正常志愿者”筛选和评估问题的重要性。应考虑采用替代策略来扩大志愿者群体。
