Rubin P, Holm S, Friberg L, Videbech P, Andersen H S, Bendsen B B, Strømsø N, Larsen J K, Lassen N A, Hemmingsen R
Department of Psychiatry, Bispebjerg Hospital, Copenhagen, Denmark.
Arch Gen Psychiatry. 1991 Nov;48(11):987-95. doi: 10.1001/archpsyc.1991.01810350027004.
To measure prefrontal and subcortical activity during a cognitive task, we examined 19 newly diagnosed schizophrenics and patients with schizophreniform psychosis. Seven healthy volunteers served as controls. The patients were drug naive or had received neuroleptics for a few days only. Cerebral blood flow distribution was depicted by single photon emission computed tomography at rest and during activation with the Wisconsin Card Sorting Test. A significant relative activation deficit in the left inferior-prefrontal region was revealed during the Wisconsin Card Sorting Test in the patient group. Furthermore, the patients had impaired striatal suppression on the left side during the cognitive task. The test performance was significantly impaired in the patients. The inability to reduce striatal activity may be due to a lack of corticostriatal feedback during prefrontal activation.
为了测量认知任务期间前额叶和皮质下的活动，我们研究了19名新诊断的精神分裂症患者和精神分裂症样精神病患者。7名健康志愿者作为对照。这些患者未服用过药物或仅服用过几天抗精神病药物。通过单光子发射计算机断层扫描描绘静息状态和威斯康星卡片分类测验激活期间的脑血流分布。在威斯康星卡片分类测验期间，患者组左侧前额叶下部区域出现明显的相对激活不足。此外，患者在认知任务期间左侧纹状体抑制功能受损。患者的测试表现明显受损。纹状体活动无法降低可能是由于前额叶激活期间缺乏皮质纹状体反馈。
