Schwartz D A, Caldwell E
Department of Pathology, Emory University School of Medicine, Atlanta, Ga.
Arch Pathol Lab Med. 1991 Nov;115(11):1141-4.
Herpes simplex infections of the placenta and its associated tissues are rarely seen and, consequently, the pathologic features are not well understood. We describe the occurrence of herpes simplex virus infection of the placenta that was limited to maternal-derived cells of the subchorionic tissue. The microscopic findings were remarkable for both the absence of inflammation and characteristic viral inclusions. However, in situ DNA hybridization, as well as immunohistochemistry using antibody to herpes simplex virus type 2, revealed herpes virus infection of decidualized cells in the decidua capsularis. The significance of this finding, and the importance of molecular techniques for the diagnosis of herpes virus infection in placental pathology, are discussed.
胎盘及其相关组织的单纯疱疹感染很少见，因此其病理特征尚未得到充分了解。我们描述了胎盘单纯疱疹病毒感染的情况，该感染仅限于绒毛膜下组织的母体来源细胞。显微镜检查结果显著，既没有炎症，也没有特征性病毒包涵体。然而，原位DNA杂交以及使用抗2型单纯疱疹病毒抗体的免疫组织化学显示，包蜕膜中蜕膜化细胞存在疱疹病毒感染。本文讨论了这一发现的意义，以及分子技术在胎盘病理学中诊断疱疹病毒感染的重要性。
