Tsinzerling A V, Indikova M G
Arkh Patol. 1988;50(12):3-12.
Structural manifestations of Herpesviridae infection, largely of herpes simplex, transmission and mode of entry were analysed and investigated by the authors on section material using light and immunofluorescent microscopy in combination with serological tests. In overall neonatal section material generalized herpetic infection was a frequent finding (4.7%). The lesions in type I and II herpes simplex were similar in manifestations. Structural evaluation of the viscera in prenatal and placental infections suggests affection of cells of epithelial origin with metamorphosis of the giant cells and a drastic increase of the nuclei exhibiting large inclusions rich in DNA. Alternative changes were more pronounced in the brain, while the destruction of the affected cells was more intensive in the lungs. Postnatal herpes simplex virus infection was also covered.
作者运用光学显微镜和免疫荧光显微镜，结合血清学检测，对疱疹病毒科感染（主要是单纯疱疹）的结构表现、传播途径及进入方式进行了分析和研究，所使用的切片材料来自新生儿。在整体新生儿切片材料中，全身性疱疹感染是常见发现（4.7%）。I型和II型单纯疱疹的病变表现相似。产前和胎盘感染中内脏的结构评估表明，上皮来源的细胞受到影响，出现巨细胞变形，细胞核急剧增多，呈现富含DNA的大包涵体。替代性变化在大脑中更为明显，而受影响细胞的破坏在肺部更为严重。文章还涵盖了产后单纯疱疹病毒感染。
