Haessler Frank, Glaser Thomas, Beneke Manfred, Pap Akos F, Bodenschatz Ralf, Reis Olaf
Department of Child and Adolescent Psychiatry, University of Rostock, Rostock, Germany.
Br J Psychiatry. 2007 May;190:447-8. doi: 10.1192/bjp.bp.105.016535.
We investigated the effects of zuclopenthixol on aggressive behaviour in patients with intellectual disabilities by randomly withdrawing it after a 6-week period of open treatment. Of the 49 patients responding to the treatment, 39 took part in a randomised withdrawal trial. The placebo subgroup (n=20) showed more aggressive behaviour as indicated by outcomes observed by external raters on the Modified Overt Aggression Scale than did the continuing subgroup (n=19). The results indicate that discontinuation of zuclopenthixolin this population leads to an increase in aggressive behaviour.
我们通过在6周的开放治疗期后随机撤药，研究了珠氯噻醇对智力残疾患者攻击行为的影响。在49名对治疗有反应的患者中，39名参与了随机撤药试验。与持续用药亚组（n = 19）相比，安慰剂亚组（n = 20）在外聘评估者根据改良的公开攻击量表观察到的结果显示，其攻击行为更多。结果表明，在该人群中停用珠氯噻醇会导致攻击行为增加。
