齐拉西酮对精神发育迟滞成人攻击性行为和破坏性行为的影响——一项停药研究的 2 年随访。
Effects of zuclopenthixol on aggressive disruptive behavior in adults with mental retardation--a 2-year follow-up on a withdrawal study.
机构信息
Clinic for Child and Adolescent Psychiatry, University of Rostock, Rostock, Germany.
出版信息
Pharmacopsychiatry. 2011 Nov;44(7):339-43. doi: 10.1055/s-0031-1291174. Epub 2011 Oct 12.
INTRODUCTION
People with mental retardation often display aggressive behavior against themselves or others making care within institutions or foster families difficult. Due to a lack of viable alternatives, antipsychotics of the first and second generations are often used for long-term treatment despite the fact that only data about short-term treatment exist.
METHODS
A short-time withdrawal trial of 12 weeks (n = 39) was extended at open label to 2 years. 31 patients received zuclopenthixol after the end of the withdrawal and were examined using the same instruments as in the withdrawal period (DAS, MOAS, CGI).
RESULTS
Patients still treated with zuclopenthixol after 2 years (n = 21) benefitted, compared to the drop-outs (n = 10). Analyses of time trends revealed an early effect of zuclopenthixol which could not be enhanced afterwards.
DISCUSSION
Zuclopenthixol proved to be safe and effective to keep a lower rate of aggressive behavior in adults with mental retardation also over a longer period of time.
简介
智障人士经常对自己或他人表现出攻击性行为，这使得在机构或寄养家庭中护理变得困难。由于缺乏可行的替代方案，第一代和第二代抗精神病药物经常被用于长期治疗，尽管只有关于短期治疗的数据。
方法
一项为期 12 周（n=39）的短期停药试验延长至 2 年的开放性标签期。31 名患者在停药后接受了氯氮平治疗，并使用与停药期间相同的工具进行检查（DAS、MOAS、CGI）。
结果
与停药的患者（n=10）相比，在 2 年后仍接受氯氮平治疗的患者（n=21）受益。时间趋势分析显示，氯氮平有早期疗效，但随后无法增强。
讨论
氯氮平被证明是安全有效的，可以在较长时间内降低智障成年人的攻击性行为发生率。
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