Hermier D, Salichon M R, Whitehead C C
INSERM Unité 321, Pavillon B Delessert, Hôpital de la Pitié, Paris, France.
Reprod Nutr Dev. 1991;31(4):419-29. doi: 10.1051/rnd:19910408.
In order to identify the mechanisms which underlie fattening in commercial birds, lean and fat broiler chickens have been selected according to 3 different criteria: abdominal fat content, plasma glucose level and plasma concentration of very-low-density lipoproteins (VLDL), the latter being the main substrate from which bird adipose tissues accumulate triglycerides. Chickens selected for high abdominal fat content displayed a higher level of VLDL and a lower level of glucose than their lean counterparts. Conversely, selection for high plasma VLDL or low plasma glucose resulted in 2 fat lines of chickens. The differences in intermediate- and low-density lipoproteins reflected a different balance in synthesis and catabolism of VLDL among the lines, whereas there was no difference in high-density lipoproteins. These data clearly demonstrate the relationship between lipid and carbohydrate metabolism and their role in the susceptibility to fattening. They suggest a greater use of carbohydrate for hepatic lipogenesis in fat chickens, resulting in a higher synthesis and secretion of VLDL and of their subsequent accumulation of triglycerides in the adipose tissue.
为了确定商业禽类育肥的潜在机制，已根据3种不同标准选择了瘦型和肥型肉鸡：腹部脂肪含量、血浆葡萄糖水平和极低密度脂蛋白（VLDL）的血浆浓度，后者是禽类脂肪组织积累甘油三酯的主要底物。选择腹部脂肪含量高的鸡比瘦型鸡表现出更高水平的VLDL和更低水平的葡萄糖。相反，选择高血浆VLDL或低血浆葡萄糖导致了2个肥型鸡品系。中密度和低密度脂蛋白的差异反映了各品系间VLDL合成与分解代谢的不同平衡，而高密度脂蛋白则无差异。这些数据清楚地证明了脂质和碳水化合物代谢之间的关系及其在育肥易感性中的作用。它们表明肥鸡肝脏脂肪生成更多地利用碳水化合物，导致VLDL合成和分泌增加，随后甘油三酯在脂肪组织中积累。
