Legrand P, Hermier D
Laboratoire de Biochimie, INRA-ENSA, Rennes, France.
Int J Obes Relat Metab Disord. 1992 Apr;16(4):289-94.
Plasma VLDL (very low density lipoprotein) content and composition have been investigated in chickens from two lines selected for high or low abdominal fat/live weight ratio, and related to the activity of hepatic delta 9 desaturase. The amounts of plasma VLDL and VLDL-triglycerides (VLDL-TG) were significantly higher in the fat line than in the lean one. Moreover, the chemical composition of VLDL was different between lines, since the greater content of TG in VLDL in the fat birds was associated with lower proportion of all other components. The fatty acid composition of VLDL-TG exhibited differences between lines: palmitoleic acid, which results from hepatic delta 9 desaturation, was in higher proportions in the fat line, whereas linoleic acid was more abundant in the lean one. The activity of liver delta 9 desaturase was significantly higher in the fat animals. A positive correlation between plasma VLDL-TG concentration and hepatic delta 9 desaturase activity in the fat line animals strongly suggests that availability of monoenoic fatty acids is involved in the control of VLDL assembly and secretion. That latter process may explain some of the differences in plasma lipids and in adiposity of the two lines of chickens.
对选自高腹脂/体重比品系和低腹脂/体重比品系的鸡的血浆极低密度脂蛋白（VLDL）含量及组成进行了研究，并将其与肝脏Δ9去饱和酶的活性相关联。脂肪品系鸡的血浆VLDL和VLDL-甘油三酯（VLDL-TG）含量显著高于瘦肉品系。此外，两品系之间VLDL的化学组成有所不同，脂肪品系鸡的VLDL中甘油三酯含量较高，而其他所有成分的比例较低。VLDL-TG的脂肪酸组成在两品系之间也存在差异：由肝脏Δ9去饱和作用产生的棕榈油酸在脂肪品系中的比例较高，而亚油酸在瘦肉品系中更为丰富。脂肪品系动物肝脏的Δ9去饱和酶活性显著更高。脂肪品系动物血浆VLDL-TG浓度与肝脏Δ9去饱和酶活性之间的正相关强烈表明，单不饱和脂肪酸的可用性参与了VLDL组装和分泌的调控。后一过程可能解释了两品系鸡在血脂和肥胖方面的一些差异。
