血浆血管性血友病因子：复发性心肌梗死和死亡的一种新危险因素。
von Willebrand factor in plasma: a novel risk factor for recurrent myocardial infarction and death.
作者信息
Jansson J H, Nilsson T K, Johnson O
机构信息
Department of Internal Medicine, Skellefteå Hospital, Sweden.
出版信息
Br Heart J. 1991 Nov;66(5):351-5. doi: 10.1136/hrt.66.5.351.
Abstract
OBJECTIVE
To evaluate as predictors of reinfarction and mortality tissue plasminogen activator antigen and activity before and after venous occlusion, plasminogen activator inhibitor, von Willebrand factor, and established risk factors.
DESIGN
Prospective study with a mean observation time of 4.9 years.
SETTING
Secondary referral centre, the Department of Internal Medicine, University Hospital of Umeå.
PATIENTS
123 consecutive survivors of myocardial infarction under the age of 70 years.
MAIN OUTCOME MEASURES
Reinfarction and deaths from all causes.
RESULTS
23 patients died and 36 patients had at least one reinfarction. High concentrations of von Willebrand factor were independently associated with both reinfarction and mortality. A history of angina at entry into the study was also independently associated with reinfarction and mortality. Hypertension was independently associated with mortality but not with reinfarction. None of the fibrinolytic or lipid variables was associated with reinfarction or death.
CONCLUSION
A high concentration of von Willebrand factor was a novel index of increased risk for reinfarction and mortality in survivors of myocardial infarction.
摘要
目的
评估静脉闭塞前后组织纤溶酶原激活物抗原及活性、纤溶酶原激活物抑制剂、血管性血友病因子以及既定危险因素作为再梗死和死亡预测指标的情况。
设计
前瞻性研究，平均观察时间为4.9年。
地点
二级转诊中心，于默奥大学医院内科。
患者
123例年龄在70岁以下的心肌梗死连续幸存者。
主要观察指标
再梗死和各种原因导致的死亡。
结果
23例患者死亡，36例患者至少发生一次再梗死。血管性血友病因子的高浓度与再梗死和死亡均独立相关。研究入组时的心绞痛病史也与再梗死和死亡独立相关。高血压与死亡独立相关，但与再梗死无关。纤溶或脂质变量均与再梗死或死亡无关。
结论
血管性血友病因子的高浓度是心肌梗死幸存者再梗死和死亡风险增加的一个新指标。
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