Chaudary Naz, Hill Richard P
Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada.
Breast Dis. 2006;26:55-64. doi: 10.3233/bd-2007-26105.
Most solid tumors contain hypoxic regions. Hypoxia affects a variety of tumor cell properties such as cell growth rate, neovascularization, metastasis and sensitivity to treatment. Breast 3cancer is the second most common cause of death in women. Nearly half of breast cancer patients treated for localized disease develop metastases and often combinations of local and systemic therapy are not curative. Tissue oxygenation measurements in human breast carcinomas have shown large areas of hypoxic tissue and immunolocalized signals of the hypoxic markers, CAIX and HIF-1 alpha, in breast cancer tissue show strong staining around necrotic regions. A wide range of genes associated with breast cancer metastasis have been reported to be upregulated under hypoxic conditions and hypoxic gene signatures are associated with poorer outcome in breast cancer. An understanding of the molecular pathways in hypoxia-induced breast cancer metastasis promises potential useful prognostic and therapeutic information.
大多数实体瘤都包含缺氧区域。缺氧会影响多种肿瘤细胞特性，如细胞生长速率、新血管生成、转移以及对治疗的敏感性。乳腺癌是女性死亡的第二大常见原因。近一半接受局部疾病治疗的乳腺癌患者会发生转移，而且局部和全身联合治疗往往无法治愈。对人类乳腺癌组织的氧合测量显示存在大片缺氧组织，并且乳腺癌组织中缺氧标志物CAIX和HIF-1α的免疫定位信号在坏死区域周围显示出强烈染色。据报道，在缺氧条件下，与乳腺癌转移相关的多种基因会上调，缺氧基因特征与乳腺癌较差的预后相关。了解缺氧诱导的乳腺癌转移中的分子途径有望提供潜在有用的预后和治疗信息。
