金精三羧酸：葡萄糖-6-磷酸脱氢酶的强效抑制剂。
Aurinetricarboxylic acid: a potent inhibitor of glucose-6-phosphate dehydrogenase.
作者信息
Hsu C L, Joshi J G
出版信息
Chem Biol Interact. 1977 Apr;17(1):61-7. doi: 10.1016/0009-2797(77)90072-2.
PMID:17474
Abstract
Inhibition by aurinetricarboxylic acid (ATA) of glucose-6-phosphate (G6P) dehydrogenase was "competitive" with respect to G6P and "mixed type" with respect to NADP+. Inhibited enzyme bound two molecules of ATA. Kinetic constants, Km, Ki at varying pH suggested possible binding of the inhibitor by the sulfhydryl of the enzyme; of the several enzymes tested only milk xanthine oxidase and G6P dehydrogenase from bovine adrenal was inhibited by ATA.
摘要
金精三羧酸（ATA）对葡萄糖-6-磷酸（G6P）脱氢酶的抑制作用，就G6P而言是“竞争性”的，而就NADP⁺而言是“混合型”的。被抑制的酶结合了两分子的ATA。在不同pH值下的动力学常数Km、Ki表明抑制剂可能与酶的巯基结合；在所测试的几种酶中，只有牛奶黄嘌呤氧化酶和牛肾上腺的G6P脱氢酶被ATA抑制。
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