Shishkina I V, Babichev V N, Pankov Iu A
Biull Eksp Biol Med. 1991 Sep;112(9):232-4.
The influence of opioid peptide on the process of formation of reproductive function in rats was studied. Administration of beta-endorphin to neonatal female rats did not affect the concentrations of oestrogen and androgen receptors in the hypothalamus and pituitary, whereas the content of testosterone receptors was significantly higher in both hypothalamus and pituitary. Chronic administration of beta-endorphin to both female and male rats does not affect the concentration of sex hormones. The results obtained indicate that chronic administration of beta-endorphin to neonatal female rats lead to formation of instable contacts in the mechanism of regulation of hypophysis gonadotropic function.
研究了阿片肽对大鼠生殖功能形成过程的影响。给新生雌性大鼠注射β-内啡肽并不影响下丘脑和垂体中雌激素和雄激素受体的浓度，而下丘脑和垂体中睾酮受体的含量均显著更高。对雌性和雄性大鼠长期注射β-内啡肽并不影响性激素的浓度。所得结果表明，对新生雌性大鼠长期注射β-内啡肽会导致垂体促性腺功能调节机制中形成不稳定联系。
