Gusev E Iu, Ponosov V L, Kevorkov N N
Biull Eksp Biol Med. 1991 Sep;112(9):271-3.
In experiments on CBA and C57BL/6 mice the generation of antibody-forming cells respectively either in the popliteal lymph nodes or spleen as well as a rate of delayed type hypersensitivity response (DTHR) on the background of subcutaneous (into foot) or intraperitoneal injection of different doses of sheep erythrocytes (from 10(4) to 10(8)) have been studied. In so doing two types of immune response can be isolated on the dependence upon the sensitivity threshold to antigen of DTHR and humoral immunity. Thus in C57BL/6 mice the antigen threshold for DTHR is of one time (in intraperitoneal immunization) or of a two times (in subcutaneous) lower order than for antibody response. In CBA line mice under subcutaneous immunization there can be seen quite an opposite picture while intraperitoneal immunization causes exact correlation of antigen threshold for cellular and humoral immune response.
在针对CBA和C57BL/6小鼠的实验中，研究了分别在腘淋巴结或脾脏中抗体形成细胞的生成情况，以及在皮下（注入足部）或腹腔注射不同剂量（从10⁴到10⁸）绵羊红细胞的背景下迟发型超敏反应（DTHR）的速率。在此过程中，根据DTHR和体液免疫对抗原的敏感性阈值，可以分离出两种类型的免疫反应。因此，在C57BL/6小鼠中，DTHR的抗原阈值比抗体反应的抗原阈值低一倍（腹腔免疫时）或两倍（皮下免疫时）。在CBA品系小鼠皮下免疫时，情况则完全相反，而腹腔免疫时细胞免疫和体液免疫反应的抗原阈值呈现出精确的相关性。
