[Relationship between interstrain differences in the magnitude of the immune response to sheep erythrocytes and the nature of inheritance of response strength to antigen dose and means of administration].

Dependence of antibody response to sheep red blood cells on the antigen doze and route of its administration was studied in mice of inbred strains (CBA C57BL/6, BALB/c) and (CBA X C57BL/6)F1 and (CBA X BALB/c)F1 hybrids. The most significant strain differences in antibody response appear at the intravenous injection of low antigen dose (5 X 10(5) cells) and intramuscular injection of mean antigen dose (5 X 10(7) cells). As the immunization dose in increased, the strain differences decrease (between CBA and C57BL/6 mice) and disappear, (between CBA and and BALB/c mice). F1 was shown to be a poor responder to the intravenous injection of low antigen dose (5 X 10(5) cells) and intramuscular injection of the mean dose and to be a higher responder to the intravenous injection of a large dose of sheep red blood cells (10(7)--10(9) cells).