Surrenti C, Maggi C A
Dipartimento di Fisiopatologia Clinica, Università di Firenze, Italy.
Ital J Gastroenterol. 1991 Feb;23(2):94-9.
In recent years great interest has been directed to study the function of capsaicin-sensitive primary afferents in the gastrointestinal tract. It has been demonstrated that these fibers not only have a sensory role but also play a local efferent function through direct and indirect effects of released neurotransmitters. Peptides released by capsaicin-sensitive nerves are involved in several functions modulating either the local blood flow or the gastrointestinal motility. The analysis of the action of released transmitters may serve to understand the physiology and pathophysiology of the gastrointestinal tract. All data here reported demonstrate that the study of capsaicin-sensitive primary afferents may be helpful to develop new pharmacological treatment of various human disease of the gastrointestinal tract.
近年来，人们对研究胃肠道中辣椒素敏感的初级传入神经的功能产生了浓厚兴趣。已经证明，这些纤维不仅具有感觉作用，还通过释放神经递质的直接和间接作用发挥局部传出功能。辣椒素敏感神经释放的肽参与调节局部血流或胃肠动力的多种功能。对释放的递质作用的分析可能有助于理解胃肠道的生理和病理生理学。这里报道的所有数据表明，对辣椒素敏感的初级传入神经的研究可能有助于开发针对各种人类胃肠道疾病的新的药物治疗方法。
