Seymour Ben, Daw Nathaniel, Dayan Peter, Singer Tania, Dolan Ray
Wellcome Trust Centre for Neuroimaging, UCL, London, United Kingdom.
J Neurosci. 2007 May 2;27(18):4826-31. doi: 10.1523/JNEUROSCI.0400-07.2007.
Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues to outcomes that simultaneously incorporate the chance of financial reward and loss, we show that striatal activation reflects positively signed prediction errors for both. Furthermore, we show functional segregation within the striatum, with more anterior regions showing relative selectivity for rewards and more posterior regions for losses. These findings mirror the anteroposterior valence-specific gradient reported in rodents and endorse the role of the striatum in aversive motivational learning about financial losses, illustrating functional and anatomical consistencies with primary aversive outcomes such as pain.
关于人类货币预测和决策的研究强调纹状体在编码财务奖励预测误差中的作用。然而，对于大脑如何编码财务损失知之甚少。通过对视觉线索与同时包含财务奖励和损失可能性的结果进行巴甫洛夫条件反射，我们发现纹状体激活反映了两者的正向预测误差。此外，我们展示了纹状体内的功能分离，前部区域对奖励表现出相对选择性，而后部区域对损失表现出相对选择性。这些发现反映了在啮齿动物中报道的前后效价特异性梯度，并支持纹状体在关于财务损失的厌恶动机学习中的作用，说明了与诸如疼痛等主要厌恶结果的功能和解剖学一致性。
