肿瘤发生过程中巨噬细胞分化改变与免疫功能障碍
Altered macrophage differentiation and immune dysfunction in tumor development.
作者信息
Sica Antonio, Bronte Vincenzo
机构信息
Istituto Clinico Humanitas, Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, Italy.
出版信息
J Clin Invest. 2007 May;117(5):1155-66. doi: 10.1172/JCI31422.
Abstract
Tumors require a constant influx of myelomonocytic cells to support the angiogenesis and stroma remodeling needed for their growth. This is mediated by tumor-derived factors, which cause sustained myelopoiesis and the accumulation and functional differentiation of myelomonocytic cells, most of which are macrophages, at the tumor site. An important side effect of the accumulation and functional differentiation of these cells is that they can induce lymphocyte dysfunction. A complete understanding of the complex interplay between neoplastic and myelomonocytic cells might offer novel targets for therapeutic intervention aimed at depriving tumor cells of important growth support and enhancing the antitumor immune response.
摘要
肿瘤需要持续涌入骨髓单核细胞来支持其生长所需的血管生成和基质重塑。这是由肿瘤衍生因子介导的，这些因子会导致持续的骨髓生成以及骨髓单核细胞在肿瘤部位的积累和功能分化，其中大多数是巨噬细胞。这些细胞积累和功能分化的一个重要副作用是它们会诱导淋巴细胞功能障碍。全面了解肿瘤细胞与骨髓单核细胞之间复杂的相互作用，可能会为治疗干预提供新的靶点，旨在剥夺肿瘤细胞重要的生长支持并增强抗肿瘤免疫反应。
相似文献
1
Altered macrophage differentiation and immune dysfunction in tumor development.肿瘤发生过程中巨噬细胞分化改变与免疫功能障碍
J Clin Invest. 2007 May;117(5):1155-66. doi: 10.1172/JCI31422.
2
Pathophysiology of tumor-associated macrophages.肿瘤相关巨噬细胞的病理生理学
Adv Clin Chem. 2008;45:199-223.
3
The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance.肿瘤相关巨噬细胞在肿瘤进展和免疫监视中的阴阳学说
Immunol Rev. 2008 Apr;222:155-61. doi: 10.1111/j.1600-065X.2008.00607.x.
4
Cancer related inflammation: the macrophage connection.癌症相关炎症：巨噬细胞的联系
Cancer Lett. 2008 Aug 28;267(2):204-15. doi: 10.1016/j.canlet.2008.03.028. Epub 2008 Apr 29.
5
Skewing the Th cell phenotype toward Th1 alters the maturation of tumor-infiltrating mononuclear phagocytes.使Th细胞表型向Th1偏移会改变肿瘤浸润单核吞噬细胞的成熟。
J Leukoc Biol. 2008 Sep;84(3):679-88. doi: 10.1189/jlb.1107729. Epub 2008 Jun 19.
6
Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages.肿瘤诱导的髓系细胞偏向：当髓系来源的抑制细胞遇上肿瘤相关巨噬细胞时
J Clin Invest. 2015 Sep;125(9):3365-76. doi: 10.1172/JCI80006. Epub 2015 Sep 1.
7
Macrophages in cancer and infectious diseases: the 'good' and the 'bad'.癌症和传染病中的巨噬细胞：“好”与“坏”。
Immunotherapy. 2011 Oct;3(10):1185-202. doi: 10.2217/imt.11.116.
8
Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer.癌巢中巨噬细胞和CD8(+) T细胞的主要浸润是IV期非小细胞肺癌患者生存的重要预测指标。
Cancer. 2008 Sep 15;113(6):1387-95. doi: 10.1002/cncr.23712.
9
Tumor-released microvesicles as vehicles of immunosuppression.肿瘤释放的微泡作为免疫抑制的载体。
Cancer Res. 2007 Apr 1;67(7):2912-5. doi: 10.1158/0008-5472.CAN-07-0520.
10
Tumour-associated macrophages (TAMS): disordered function, immune suppression and progressive tumour growth.肿瘤相关巨噬细胞（TAMS）：功能紊乱、免疫抑制与肿瘤进展
J R Coll Surg Edinb. 2000 Feb;45(1):1-16.
引用本文的文献
1
Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments.肿瘤微环境中肿瘤相关巨噬细胞的双重作用及治疗靶点
Signal Transduct Target Ther. 2025 Aug 25;10(1):268. doi: 10.1038/s41392-025-02325-5.
2
Reactive Oxygen Species in Asthma: Regulators of Macrophage Polarization and Therapeutic Implications: A Narrative Review.哮喘中的活性氧：巨噬细胞极化的调节因子及其治疗意义：一篇叙述性综述
J Asthma Allergy. 2025 Jul 25;18:1129-1146. doi: 10.2147/JAA.S529371. eCollection 2025.
3
Immunomodulatory effects of photothermal therapy in breast cancer: advances and challenges.光热疗法在乳腺癌中的免疫调节作用：进展与挑战
Front Immunol. 2025 Jul 4;16:1544693. doi: 10.3389/fimmu.2025.1544693. eCollection 2025.
4
Natural killer cell therapy in hepatocellular carcinoma: a comprehensive review.肝细胞癌中的自然杀伤细胞疗法：全面综述
Discov Oncol. 2025 Jul 16;16(1):1348. doi: 10.1007/s12672-025-03138-2.
5
Tumor Microenvironment, Inflammation, and Inflammatory Prognostic Indices in Diffuse Large B-Cell Lymphomas: A Narrative Review.弥漫性大B细胞淋巴瘤中的肿瘤微环境、炎症及炎症性预后指标：一篇叙述性综述
Int J Mol Sci. 2025 Jun 13;26(12):5670. doi: 10.3390/ijms26125670.
6
Curdlan: a microbial biopolymer of multifarious applications for a sustainable environment.凝胶多糖：一种用于可持续环境的具有多种应用的微生物生物聚合物。
Protoplasma. 2025 Jun 24. doi: 10.1007/s00709-025-02082-w.
7
Macrophage polarization in disease therapy: insights from astragaloside IV and cycloastragenol.疾病治疗中的巨噬细胞极化：黄芪甲苷和环黄芪醇的启示
Front Pharmacol. 2025 May 23;16:1598022. doi: 10.3389/fphar.2025.1598022. eCollection 2025.
8
Myeloid-Derived Suppressor Cells in Cancer: Mechanistic Insights and Targeted Therapeutic Innovations.癌症中的髓源性抑制细胞：机制洞察与靶向治疗创新
MedComm (2020). 2025 May 31;6(6):e70231. doi: 10.1002/mco2.70231. eCollection 2025 Jun.
9
Macrophages and the immune microenvironment in OPMDs: a systematic review of the literature.眼咽型肌营养不良症中的巨噬细胞与免疫微环境：文献系统综述
Front Oral Health. 2025 May 13;6:1605978. doi: 10.3389/froh.2025.1605978. eCollection 2025.
10
Sulfated chitosan directs the recovery of ischemic stroke by attenuating the inflammatory cascade.硫酸化壳聚糖通过减弱炎症级联反应来指导缺血性中风的恢复。
Theranostics. 2025 Apr 28;15(12):5870-5889. doi: 10.7150/thno.111681. eCollection 2025.
本文引用的文献
1
The terminology issue for myeloid-derived suppressor cells.髓源性抑制细胞的术语问题。
Cancer Res. 2007 Jan 1;67(1):425; author reply 426. doi: 10.1158/0008-5472.CAN-06-3037.
2
Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: correlations with prognostic parameters.乳腺肿瘤中的微血管密度、VEGF表达及肿瘤相关巨噬细胞：与预后参数的相关性
J Exp Clin Cancer Res. 2006 Sep;25(3):365-72.
3
p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance.肿瘤相关巨噬细胞中p50核因子-κB的过表达抑制M1炎症反应和抗肿瘤抗性。
Cancer Res. 2006 Dec 1;66(23):11432-40. doi: 10.1158/0008-5472.CAN-06-1867.
4
Immunosuppressive strategies that are mediated by tumor cells.由肿瘤细胞介导的免疫抑制策略。
Annu Rev Immunol. 2007;25:267-96. doi: 10.1146/annurev.immunol.25.022106.141609.
5
Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function.磷酸二酯酶-5抑制通过降低髓源性抑制细胞功能增强内源性抗肿瘤免疫力。
J Exp Med. 2006 Nov 27;203(12):2691-702. doi: 10.1084/jem.20061104. Epub 2006 Nov 13.
6
Interferons, immunity and cancer immunoediting.干扰素、免疫与癌症免疫编辑
Nat Rev Immunol. 2006 Nov;6(11):836-48. doi: 10.1038/nri1961.
7
L-arginine availability regulates T-lymphocyte cell-cycle progression.L-精氨酸的可利用性调节T淋巴细胞的细胞周期进程。
Blood. 2007 Feb 15;109(4):1568-73. doi: 10.1182/blood-2006-06-031856. Epub 2006 Oct 5.
8
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells.肿瘤诱导出一部分对CD8+ T细胞具有免疫抑制活性的炎性单核细胞。
J Clin Invest. 2006 Oct;116(10):2777-90. doi: 10.1172/JCI28828.
9
TCR zeta down-regulation under chronic inflammation is mediated by myeloid suppressor cells differentially distributed between various lymphatic organs.慢性炎症下TCR ζ链的下调由不同分布于各种淋巴器官的髓样抑制细胞介导。
J Immunol. 2006 Oct 1;177(7):4763-72. doi: 10.4049/jimmunol.177.7.4763.
10
Targeting tumor-associated macrophages as a novel strategy against breast cancer.将肿瘤相关巨噬细胞作为对抗乳腺癌的新策略。
J Clin Invest. 2006 Aug;116(8):2132-2141. doi: 10.1172/JCI27648.
Zotero 插件