Valenti Roberta, Huber Veronica, Iero Manuela, Filipazzi Paola, Parmiani Giorgio, Rivoltini Licia
Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Cancer Res. 2007 Apr 1;67(7):2912-5. doi: 10.1158/0008-5472.CAN-07-0520.
Tumor-released microvesicles, or exosomes, which are abundant in the body fluids of patients with cancer, are likely to be involved in tumor progression. We recently showed that microvesicles released by human melanoma and colorectal carcinoma cells can promote the differentiation of monocytes to myeloid-derived suppressor cells which support tumoral growth and immune escape. These findings underscore an important role for these extracellular organelles in remodeling tumor-stromal interactions to promote malignancy.
肿瘤释放的微泡，即外泌体，在癌症患者的体液中大量存在，可能参与肿瘤进展。我们最近发现，人类黑色素瘤和结肠癌细胞释放的微泡可促进单核细胞分化为髓源性抑制细胞，后者支持肿瘤生长和免疫逃逸。这些发现强调了这些细胞外细胞器在重塑肿瘤-基质相互作用以促进恶性肿瘤发展方面的重要作用。
