Ershov Iu V
Prikl Biokhim Mikrobiol. 2007 Mar-Apr;43(2):133-57.
Specific inhibitors of 2-C-methylerythritol phosphate pathway (MEP-pathway), including compounds obtained based on its metabolites, may compose a new class of antibiotics combining high efficiency and low toxicity. MEP-pathway of isoprenoid biosynthesis is a promising target in identifying new herbicides, immunomodulators, and other physiologically active compounds.
2-甲基赤藓糖醇磷酸途径(MEP途径)的特异性抑制剂,包括基于其代谢产物获得的化合物,可能构成一类兼具高效和低毒的新型抗生素。类异戊二烯生物合成的MEP途径是鉴定新型除草剂、免疫调节剂及其他生理活性化合物的一个有前景的靶点。