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[作为新型抗生素、除草剂和免疫调节剂鉴定靶点的类异戊二烯生物合成的2-C-甲基-D-赤藓糖醇磷酸途径（综述）]

[2-C-Methylerythritol phosphate pathway of isoprenoid biosynthesis as a target in identifying of new antibiotics, herbicides, and immunomodulators (Review) ].

作者信息

Ershov Iu V

出版信息

Prikl Biokhim Mikrobiol. 2007 Mar-Apr;43(2):133-57.

PMID:17476799
Abstract

Specific inhibitors of 2-C-methylerythritol phosphate pathway (MEP-pathway), including compounds obtained based on its metabolites, may compose a new class of antibiotics combining high efficiency and low toxicity. MEP-pathway of isoprenoid biosynthesis is a promising target in identifying new herbicides, immunomodulators, and other physiologically active compounds.

摘要

2-甲基赤藓糖醇磷酸途径（MEP途径）的特异性抑制剂，包括基于其代谢产物获得的化合物，可能构成一类兼具高效和低毒的新型抗生素。类异戊二烯生物合成的MEP途径是鉴定新型除草剂、免疫调节剂及其他生理活性化合物的一个有前景的靶点。

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