锂离子对大鼠血管升压素抗利尿作用的影响。
The effects of lithium ions on the antidiuretic action of vasopressin in the rat.
作者信息
Jenner F A, Macneil S
出版信息
Br J Pharmacol. 1975 Dec;55(4):527-34. doi: 10.1111/j.1476-5381.1975.tb07428.x.
1 The effect of intravenous infusion of lithium, 2.56 mumol/min on the antidiuretic responses to antidiuretic hormone (ADH), adenosine triphosphate (ATP), 3'-5' adenosine cylic monophosphate (cyclic AMP) and theophyline was studied in water-loaded, alcohol-anaesthetized rats. 2 Lithium reversibly inhibits the antidiuretic response to all concentrations of ADH, depressing the maximum response but not changing the amount required for half maximal response. 3 The rate of increase of serum lithium relates more clearly to the inhibitory effect than does the serum concentration. 4 Sodium concentrations in the renal papilla seem to fall when serum lithium levels are rising. 5 Lithium inhibits the antidiuretic response to ATP and cyclic AMP but does not inhibit the response to theophyline.
在水负荷、酒精麻醉的大鼠中，研究了以2.56 μmol/分钟的速率静脉输注锂对血管升压素（ADH）、三磷酸腺苷（ATP）、3'-5'-环磷酸腺苷（环磷腺苷）和茶碱的抗利尿反应的影响。
锂可逆性抑制对所有浓度ADH的抗利尿反应，降低最大反应，但不改变半数最大反应所需的量。
血清锂的升高速率比血清浓度更明显地与抑制作用相关。
当血清锂水平升高时，肾乳头中的钠浓度似乎会下降。
锂抑制对ATP和环磷腺苷的抗利尿反应，但不抑制对茶碱的反应。
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