Roy R, Chandrasekhar D, Pujari P
Department of Zoology, Taleigao Plateau, Goa University, Goa 403 206, India.
Indian J Exp Biol. 2007 Apr;45(4):367-70.
The administration of galactosamine in omega-3 polyunsatu-rated fatty acid (PUFA) supplemented mice resulted in lesser amount of damage in the liver tissue compared to the mice without prior supplementation of fish oil. Only 50% elevation in the plasma total bilirubin was detected in omega-3 supplemented mice injected with galactosamine over those supplemented with omega-3 without galactosomine injection. The results suggest that very long chain omega-3 PUFA like eicosapentaenoic and docosahexaenoic acid may act as preventive agent for hepatic cirrhosis in Mus musculus.
与未预先补充鱼油的小鼠相比，在补充了ω-3多不饱和脂肪酸（PUFA）的小鼠中给予半乳糖胺后，肝组织损伤量较少。在注射了半乳糖胺的ω-3补充小鼠中，血浆总胆红素仅比未注射半乳糖胺的ω-3补充小鼠升高了50%。结果表明，像二十碳五烯酸和二十二碳六烯酸这样的极长链ω-3 PUFA可能作为小家鼠肝硬化的预防剂。
