Yin Zhenyu, Jiang Guoping, Fung John J, Lu Lina, Qian Shiguang
Department of Immunology, Cleveland Clinic, Cleveland, OH 44195, USA.
Microsurgery. 2007;27(4):328-32. doi: 10.1002/micr.20366.
The authors have demonstrated a strong T-cell inhibitory activity of hepatic stellate cells (HSC), which may participate in the establishment of hepatic tolerance. The underlying mechanism is not completely understood. This study showed that intercellular adhesion molecule 1 (ICAM-1) was constitutively expressed on HSC, and up-regulated upon activation. ICAM-1 knockout mice was used to analyze the role of ICAM-1 expressed on HSC, and showed that deficiency in ICAM-1 expression partially reverses HSC immune inhibitory activity both in vitro and in vivo, but did not significantly affect their capacity to induce T-cell apoptosis.
作者已证明肝星状细胞（HSC）具有很强的T细胞抑制活性，其可能参与肝脏耐受性的建立。潜在机制尚未完全明确。本研究表明，细胞间黏附分子1（ICAM-1）在HSC上组成性表达，并在激活后上调。利用ICAM-1基因敲除小鼠分析HSC上表达的ICAM-1的作用，结果显示，ICAM-1表达缺陷在体外和体内均可部分逆转HSC的免疫抑制活性，但对其诱导T细胞凋亡的能力无显著影响。
