Balasundaram Ganesan, Webster Thomas J
Divisions of Engineering and Orthopaedics, Brown University, Box D, 224 Barus and Holley, 182 Hope Street, Providence, RI 02912, USA.
Macromol Biosci. 2007 May 10;7(5):635-42. doi: 10.1002/mabi.200600270.
This review paper presents many exciting nanotechnology and tissue engineering approaches involving polymers that have enormous potential impact on human health care, particularly for orthopedic applications. As scaffolds play a vital role in tissue engineering, the feasibility of designing polymeric nano-featured scaffolds is reviewed. Although bone is a very diverse tissue providing different functions within the body, recent work has resulted in new biomaterials with promise to solve orthopedic problems. Significant advancements in orthopedic care are required since recent data highlight a less than 15 year lifetime of current hip implants. Nanotechnology (or the use of nanomaterials) is providing a wide range of new materials to improve the current short lifetimes of orthopedic implants.
这篇综述文章介绍了许多令人兴奋的纳米技术和组织工程方法，这些方法涉及对人类医疗保健具有巨大潜在影响的聚合物，特别是在骨科应用方面。由于支架在组织工程中起着至关重要的作用，因此对设计具有纳米特征的聚合物支架的可行性进行了综述。尽管骨骼是一种非常多样化的组织，在体内发挥着不同的功能，但最近的研究成果产生了有望解决骨科问题的新型生物材料。鉴于最近的数据表明目前的髋关节植入物使用寿命不到15年，骨科护理方面需要取得重大进展。纳米技术（或纳米材料的使用）正在提供各种各样的新材料，以改善目前骨科植入物较短的使用寿命。
