Messersmith D J, Fabrazzo M, Mocchetti I, Kromer L F
Department of Anatomy and Cell Biology, Georgetown University School of Medicine, Washington, DC 20007.
Brain Res. 1991 Aug 23;557(1-2):293-7. doi: 10.1016/0006-8993(91)90147-n.
At two weeks post-transplantation, sciatic nerves inserted into the lesioned septo-hippocampal pathway contain NGF levels more than twice that of normal nerves. These transplanted nerves also contain regenerating cholinergic axons. Moreover, transplanted animals exhibit septal NGF levels that are significantly greater than in animals with lesions only. These results suggest a role for NGF in the ingrowth of axons into the transplants and in the increase in ChAT(+) septal neurons previously observed at this post-transplant time.
移植后两周，植入受损隔区-海马通路的坐骨神经所含神经生长因子（NGF）水平比正常神经高出两倍多。这些移植的神经还含有正在再生的胆碱能轴突。此外，移植动物的隔区NGF水平显著高于仅患有损伤的动物。这些结果表明，NGF在轴突长入移植体以及此前在移植后这个时间点观察到的隔区ChAT（+）神经元增加方面发挥了作用。
