Collins F, Crutcher K A
Synergen, Inc., Boulder, CO 80301.
Brain Res. 1989 Jun 26;490(2):355-60. doi: 10.1016/0006-8993(89)90254-0.
Several laboratories have documented an increase in hippocampal nerve growth factor (NGF) levels, measured with biological or immunological assays, within 1-2 weeks following septal lesions or fimbria/fornix transections. In the present study we have determined the increase in NGF-like biological activity in medium conditioned by hippocampal slices at more prolonged times following medial septal lesion. In contrast to reports based on immunological assays, which demonstrate a transient increase in hippocampal NGF, elevated NGF-like biological activity was present in hippocampal slice-conditioned medium up to one year after a medial septal lesion.
几个实验室已经证明，在隔区损伤或穹窿/穹窿海马伞横断后的1-2周内，通过生物学或免疫学检测方法测得海马神经生长因子（NGF）水平会升高。在本研究中，我们测定了内侧隔区损伤后更长时间内海马切片条件培养基中NGF样生物活性的增加情况。与基于免疫学检测的报告不同，后者显示海马NGF有短暂升高，而在内侧隔区损伤后长达一年的时间里，海马切片条件培养基中都存在升高的NGF样生物活性。
