Kleven M S, Seiden L S
Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637.
Brain Res. 1991 Aug 23;557(1-2):340-3. doi: 10.1016/0006-8993(91)90157-q.
Rats were treated with daily injections of saline or cocaine (20 mg/kg i.p. x 15 days) and, beginning 24 h after the last injection, administered saline or methamphetamine (6.25-50 mg/kg s.c., BID x 4 days) and sacrificed two weeks later. Repeated daily administration of cocaine potentiated the long-lasting striatal dopamine depletions caused by methamphetamine. The results suggest that human use of cocaine may increase the likelihood of neurotoxicity resulting from ingestion of high doses of methamphetamine.
给大鼠每日注射生理盐水或可卡因（腹腔注射20毫克/千克，共15天），并在最后一次注射后24小时开始，给予生理盐水或甲基苯丙胺（皮下注射6.25 - 50毫克/千克，每日两次，共4天），两周后处死。每日重复给予可卡因会增强甲基苯丙胺引起的纹状体多巴胺的长期耗竭。结果表明，人类使用可卡因可能会增加因摄入高剂量甲基苯丙胺而导致神经毒性的可能性。
