The main role of vitamin D: seasonal regulation of vital functions. High-resolution target recognition leads to a new paradigm and advanced drug development.

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作者信息

Stumpf Walter E

出版信息

Eur J Drug Metab Pharmacokinet. 2007 Jan-Mar;32(1):1-6. doi: 10.1007/BF03190983.

DOI:10.1007/BF03190983

PMID:17479537

Abstract

摘要

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The main role of vitamin D: seasonal regulation of vital functions. High-resolution target recognition leads to a new paradigm and advanced drug development.

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引用本文的文献

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Histopharmacology.组织药理学

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Vitamin D and the digestive system.维生素D与消化系统

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Salivary glands epithelial and myoepithelial cells are major vitamin D targets.唾液腺上皮细胞和肌上皮细胞是维生素D的主要作用靶点。

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本文引用的文献

New insights into the mechanisms involved in the pleiotropic actions of 1,25dihydroxyvitamin D3.对1,25-二羟基维生素D3多效性作用机制的新见解。

Ann N Y Acad Sci. 2006 Apr;1068:194-203. doi: 10.1196/annals.1346.025.

The dose makes the medicine.

Drug Discov Today. 2006 Jun;11(11-12):550-5. doi: 10.1016/j.drudis.2006.04.012.

Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers.维生素D：对预防骨质疏松症、心血管疾病、1型糖尿病、自身免疫性疾病及某些癌症很重要。

South Med J. 2005 Oct;98(10):1024-7. doi: 10.1097/01.SMJ.0000140865.32054.DB.

Vitamin D.维生素D。

Am J Physiol Renal Physiol. 2005 Jul;289(1):F8-28. doi: 10.1152/ajprenal.00336.2004.

Drug localization and targeting with receptor microscopic autoradiography.受体显微放射自显影技术用于药物定位与靶向研究。

J Pharmacol Toxicol Methods. 2005 Jan-Feb;51(1):25-40. doi: 10.1016/j.vascn.2004.09.001.

1Alpha,25-dihydroxyvitamin D(3) - not just a calciotropic hormone.1α,25-二羟基维生素D(3)——不仅仅是一种钙调节激素。

Nephron. 2002 Aug;91(4):576-81. doi: 10.1159/000065015.

Vitamin D sites and mechanisms of action: a histochemical perspective. Reflections on the utility of autoradiography and cytopharmacology for drug targeting.维生素D的作用位点与作用机制：组织化学视角。关于放射自显影术和细胞药理学在药物靶向应用中的思考。

Histochem Cell Biol. 1995 Dec;104(6):417-27. doi: 10.1007/BF01464331.

Vitamin D--soltriol the heliogenic steroid hormone: somatotrophic activator and modulator. Discoveries from histochemical studies lead to new concepts.维生素D——骨化三醇，一种由阳光产生的类固醇激素：生长激素的激活剂和调节剂。组织化学研究的发现带来了新的概念。

Histochemistry. 1988;89(3):209-19. doi: 10.1007/BF00493142.

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